Huh, Iksoo

Huh, Iksoo

Assistant Professor
Statistics in Public Health and Nursing


Department of Statistics, Seoul National University (PhD)
Department of Statistics, Seoul National University (BS)


Assistant professor, College of Nursing, Seoul National University.
Postdoctoral researcher, Department of Biology, Georgia Institute of Technology.
Postdoctoral researcher, Seoul National University

Research Interests

Genetic epidemiology, Epigenomics.


■ I Huh, I Mendizabal, T Park, SV Yi, (2018) Functional conservation of sequence determinants at rapidly evolving regulatory regions across mammals. Plos Computational Biology , doi.org/10.1371/journal.pcbi.1006451.
■ D Sun, I Huh, WM Zinzow-Kramer, DL Maney, SV Yi, (2018) Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes, Proceedings of the National Academy of Sciences of the United States of America, doi.org/10.1073/pnas.1717721115.
■ I Huh, X Wu, T Park, S Yi, (2017) Detecting differential DNA methylation from sequencing of bisulfite converted DNA of diverse species, Briefings in Bioinformatics, doi: 10.1093/bib/bbx077.
■ DW Lee, SW Han, Y Cha, JM Cha, HW Kim, J Lyu, H Han, H Kim, H Jang, D Bang, I Huh, T Park, JK Won, SY Jeong, KJ Park, GH Kang, TY Kim. (2017) Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer, Cancer, 123(18):3513-3523
■ YJ Kim, I Huh, JY Kim, et al., (2017) Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation, Nutrients, 9(3):233
■ C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, KJ Gaulton, C Ma, P Fontanillas, L Moutsianas, DJ McCarthy, MA Rivas, JRB Perry, XI Sim, TW Blackwell, NR Robertson, NW Rayner, P Cingolani, AE Locke, JF Tajes, HM Highland, J Dupuis, PS Chines, CM Lindgren, C Hartl, AU Jackson, H Chen, JR Huyghe, M van de Bunt, RD Pearson, A Kumar, M M?ller-Nurasyid, N Grarup, HM Stringham, ER Gamazon, J Lee, Y Chen, RA Scott, JE Below, P Chen, J Huang, MJ Go, ML Stitzel, D Pasko, SCJ Parker, TV Varga, T Green, NL Beer, AG Day-Williams, T Ferreira, T Fingerlin, M Horikoshi, C Hu, I Huh, et al, (2016), The genetic architecture of type 2 diabetes, Nature, 536(7614):41-47.
■ HR Chang, S Nam, J Lee, JH Kim, HR Jung, H Park, S Park, YZ Ahn, I Huh, et al., (2016) Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer, Oncotarget, 7(49):81435-81451
■ S Oh, I Huh, SY Lee, T Park, (2016) Analysis of multiple related phenotypes in genome-wide association studies, Journal of Bioinformatics and Computational Biology, 14(5): 1644005
■ S Ryu, I Huh, EY Cho, et al. (2016) Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients, Pharmacopsychiatry, 49(2):51-56.
■ SY Yang, I Huh, JH Baek, et al. (2015) Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries, Plos One, 10(9): e0139413
■ I Huh, S Oh, MS Kwon, T Park, (2015) An efficient stepwise, statistical test to identify multiple linked human genetic variants associated with specific phenotypic traits, Plos One 10(9): e0138700
■ Y Cho, S Ryu, I Huh, EY Cho, H Oh, YS Le, WK Lee, T Park, JS Kwon, KS Hong, (2015) Effects of genetic variations in NRG1 on cognitive domains in patients with schizophrenia and healthy subjects, Psychiatric Genetics 25(4):147-154
■ I Huh, T Park (2015) Multifactor dimensionality reduction analysis of multiple binary traits for gene-gene interaction Int. J. Data Mining and Bioinformatics, 14(4):293-304
■ EY Kim, SH Kim, SJ Rhee, I Huh, K Ha, J Kim, JS Chang, DH Yoon, T Park, YM Ahn, (2015) Relationship between thyroid-stimulating hormone levels and risk of depression among the general population with normal free T4 levels, Psychoneuroendocrinology, 58:114?119
■ JS Kim, TH Ha, JS Chang, YS Park, I Huh, J Kim, KS Hong, T Park, K Ha (2015), Seasonality and its distinct clinical correlates in bipolar II disorder, Psychiatry Res , 225(3):540-544
■ JH Baek, JS Kim, I Huh, K Lee, JH Park, T Park, K Ha, KS Hong, (2015) Prevalence, behavioral manifestations and associated individual and climatic factors of seasonality in the Korean general population, Comprehensive Psychiatry, 57:148?154
■ I Huh, SV Yi, T Park, (2015), A test for detecting differentially methylated regions, Bioinformatics and Biomedicine (BIBM), 2015 IEEE International Conference, 305-308.
■ HR Chang, S Nam, MC Kook, KT Kim, X Liu, H Yao, HR Jung, R Lemos Jr, HH Seo, HS Park, Y Gim, D Hong, I Huh, YW Kim, D Tan, CG Liu, G Powis, T Park, H Liang, YH Kim, (2014) HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer, GUT , 65(1):19-32
■ I Huh, X Yang, T Park, SV Y, (2014) Bis-class: a new classification tool of methylation status using bayes classifier and local methylation information BMC genomics, 15:608
■ JH Shin, T Park and, IS Huh (2013) Nursing Staffing and Quality of Life in Western New York Nursing Homes. Western Journal of Nursing Research, 36, 788-805.
■ JH Namkung, JE Lee, E Kim, IS Huh, T Park, ES Shin, EY Cho, JM Yang, (2013), Single nucleotide polymorphism in the FLT4 gene is associated with atopic dermatitis in Koreans , Cytokine, 62(1): 110-114
■ KI Kim, IS Huh, IW Kim, T Park, KS Ahn, SS Yoon, JH Yoon, JM Oh, (2013) Combined interaction of multi-locus genetic polymorphisms in cytarabine arabinoside metabolic pathway on clinical outcomes in adult acute myeloid leukaemia (AML) patients, Eur J Cancer.49(2):403-10.
■ HY Park, CR Kim, IS Huh, MY Jung, EY Seo, JH Park, DY Lee and JM Yang, (2013) Staphylococcus aureus colonization in acute and chronic skin lesions of patients with atopic dermatitis, Ann Dermatol. 25(4):410-416
■ I Huh, J Zeng, T Park, SV Yi, (2013) DNA methylation and transcriptional noise. Epigenetics & Chromatin, 6:9
■ JH Yoo, S Ryu, EY Cho, IS Huh, T Park, YS Lee, JS Kwon, KS Hong, (2012), Association Analyses of ST8SIA2 Genetic Polymorphisms with Schizophrenia in the Korean Population, Korean J Biol Psychiatry 2012;19:140-145
■ HY Park, IS Huh, DY Lee, JM Yang, (2011), Serum Zinc Levels in Patients with Atopic Dermatitis, Annals of Dermatology, 49(8):670-675
■ IS Kim, HJ Kim, HS Yang, E Kim, IS Huh, and JM Yang, (2011) IL-31 serum protein and tissue mRNA levels in patients with atopic dermatitis, Ann Dermatol, 23(4):468-473
■ IS Huh, S Oh, T Park, (2011), A chi-square test for detecting multiple joint genetic variants in genome-wide association studies, 2011 IEEE International Conference on Bioinformatics and Biomedicine, Workshops, 708-713, Atlanta, USA
■ S Lee, MS Kwon, IS Huh and, T Park (2011) CUDA-LR : CUDA-accelerated Logistic Regression Analysis Tool for Gene-Gene Interaction for Genome-Wide Association Study 2011 IEEE International Conference on Bioinformatics and Biomedicine, Workshops, 691-695, Atlanta, USA